Objective:

To explore the evolution and benefits of tissue-addition techniques for managing keratoconus and irregular cornea conditions, emphasizing improved visual outcomes and patient quality of life.

Key Findings:

• Tissue-based reshaping can improve uncorrected and spectacle-corrected visual acuity, with specific improvements noted in clinical trials.
• CAIRS and CTAK offer advantages over traditional ICRS by using donor tissue for reshaping, leading to better patient outcomes.
• CTAK demonstrated significant improvements in visual acuity and corneal shape in clinical trials, with specific metrics to support these claims.

Interpretation:

Tissue-addition techniques represent a promising advancement in the management of keratoconus, providing better visual outcomes while preserving future surgical options for patients.

Limitations:

• Higher costs and logistical challenges associated with tissue processing, including scheduling and coordination with eye banks.
• Variability in segment geometry and surgical demands in CAIRS, which may affect outcomes.

Conclusion:

Tissue-addition reshaping techniques are valuable for patients with moderate to advanced keratoconus, enhancing visual function and reducing dependence on contact lenses, while offering a new pathway in keratoconus management.