Alcon announced the introduction of Clareon PanOptix Pro intraocular lens (IOL) for cataract patients in the United States. In a company press release, Alcon said PanOptix Pro leverages proprietary ENLIGHTEN NXT Optical technology which delivers the highest reported light utilization of any trifocal IOL—and the lowest light scatter.1-3,6-10,§,** These enhancements also provide more uninterrupted light distribution from distance to near, and a 16% increase in optical image contrast between distance and intermediate.1,† The company said PanOptix Pro builds on the clinically-proven low visual disturbance profile, high spectacle independence and exceptionally high patient satisfaction of PanOptix.1,2,11,12,**,°,Δ
“As the global leader in eye care, we are committed to improving our technologies to advance patient outcomes through rigorous, world-class R&D—even with our leading products like PanOptix,” said Rob Scott, vice president, Intraocular Devices, R&D, Alcon, in the press release. “Our team looked at hundreds of design options, ultimately landing on a targeted diffractive refinement that helped us recover 50% of light lost to scatter, and reposition it to a beneficial focal point for PanOptix Pro.1,2,13-19,* This allowed for specific enhancements while maintaining the features that have driven the success of PanOptix—the world’s most implanted trifocal IOL.”3-5,‡
Kerry Solomon, MD, Medical Director at Carolina Eyecare Physicians, LLC, added: “PanOptix has been a game-changer in my practice, allowing me to reliably offer many of my patients complete freedom from glasses after cataract surgery.”11,20 “I was excited to learn that Alcon evolved this leading technology for more light utilization and less light scatter.1,2,* My early patient results with PanOptix Pro support that this advancement builds on the well-established performance of PanOptix.”
According to the company, PanOptix Pro will be the first presbyopia-correcting IOL available in the US from Alcon in the single-use Clareon AutonoMe preloaded delivery system. PanOptix Pro will also be available for use with the Clareon Monarch IV delivery system beginning in 2026.12 PanOptix Pro offers powers ranging from +6.0 through +30.0 diopters (in 0.5 diopter increments), +31.0 through +34.0 diopters (in 1.0 diopter increments), with a +2.17 diopter intermediate and a +3.25 diopter near add power. Like all Alcon IOLs, PanOptix Pro will be available with blue light and ultraviolet filtering.12
According to Alcon, PanOptix Pro has been introduced to select practices across the US, with broad commercial availability in May. Additional markets will begin rollout in late 2025.
*Compared to Clareon PanOptix. PanOptix has 88% light utilization (12% scatter light)/PanOptix Pro has 94% light utilization (6% scatter light).†Based on bench-measured, average white-light modular transfer function (MTF) from 0 to 70 lp/mm at 3mm aperture, compared to PanOptix.
‡Based on worldwide IOL unit sales of Clareon PanOptix and AcrySof® IQ PanOptix through Q1, 2024.
§Based on manufacturer reported values and respective methodology for Clareon PanOptix, Envista Envy, AT Elana, Gemetric and Rayner.
**Based on bench and vision simulator studies.
°Based on data for AcrySof IQ PanOptix Trifocal IOL.ΔResponse to the following question on IOLSAT questionnaire (Version 1.0, December 20, 2018) at 6 months post-op "Given your vision today, if you had to do it all over, would you have the same lenses implanted again?"; n=127.
References
- Alcon data on file, 2025. REF-25218
- Alcon data on file, 2015. REF-08546
- Alcon data on file, 2024. REF-25221
- Alcon data on file, 2024. REF-23554
- MarketScope LLC. 2023 IOL Market Report: Global Analysis for 2022 to 2028. St. Louis, MO: MarketScope LLC; 2023.
- Muzychuk, A. Defocus Curve Performance of a Novel Hydrophobic Acrylic Trifocal Intraocular Lens: A prospective, Multicenter Canadian Study. ASCRS Annual Meeting, April 5-8, Boston.
- Rayner Professional Website.https://rayner.com/en/iol/trifocal/rayone-trifocal/. Accessed March 2025.
- Carones F. New Concept of Light Distribution for Bilateral Trifocal IOL Implantation. AAO. 2022;2022:53.
- ZEISS AT LISA tri family. Supplement in Cataract and Refractive Surgery Today (Europe), September 2014.
- Zeiss Cataract Insights: Laying the Myth or Reality; Digitalization enhances cataract surgery? Supplement in Ophthalmology Times, Europe; May 22, 2024; https://europe.ophthalmologytimes.com/zeiss-cataract-insight-series?page=1. Accessed March 2025.
- Zhu D, Ren S, Mills K, Hull J, Dhariwal M. Rate of complete spectacle independence with a trifocal intraocular lens: A systematic literature review and meta-analysis. Ophthalmol Ther. 2023;12(2):1157-1171.doi:10.1007/s40123-023-00657-5.
- Clareon PanOptix Pro Trifocal Hydrophobic Acrylic IOL Model PXYWT0 2024 Directions for Use.
- Kohnen T, Lapid-Gortzak R, Ramamurthy D, et al. Clinical outcomes after bilateral implantation of a diffractive trifocal intraocular lens: A worldwide pooled analysis of prospective clinical investigations. Clin Ophthalmol. 2023;Volume 17:155-163. doi:10.2147/opth.s377234.
- Charness N, Dijkstra K, Jastrzembski T, Weaver S, Champion M. Monitor viewing distance for younger and older workers. Proceedings of the Human Factors and Ergonomics Society Annual Meeting. 2008;52(19):1614-1617. doi:10.1177/154193120805201965.
- Government of Canada CC for OH and S. CCOHS: Office ergonomics. Canadian Centre for Occupational Health and Safety. April 25, 2023. Accessed May 9, 2023. https://www.ccohs.ca/oshanswers/ergonomics/office/.
- Gundersen KG, Potvin R. Trifocal intraocular lenses: A comparison of the visual performance and quality of vision provided by two different lens designs. Clin Ophthalmol. 2017; Volume 11:1081-1087. doi:10.2147/opth.s136164.
- Kohnen T, Titke C, Böhm M. Trifocal intraocular lens implantation to treat visual demands in various distances following lens removal. Am J Ophthalmol. 2016;161. doi:10.1016/j.ajo.2015.09.030.
- Lwowski C, Pawlowicz K, Petermann K, et al. Visual and patient-reported factors leading to satisfaction after implantation of diffractive extended depth-of-focus and trifocal intraocular lenses. J Cataract Refract Surg. 2022;48(4):421-428. doi:10.1097/j.jcrs.0000000000000780.
- Alcon data on file, 2024. REF-25903
- Clareon PanOptix Trifocal Hydrophobic Acrylic IOL. Product Information. 2021.