Objective:

To evaluate the durability of intraocular lens (IOL) materials after exposure to space conditions for approximately 6 months.

Approach:

• Study Design: The Joint Assessment Of Material Exposure In Space (JAMES) project sent 135 unpackaged IOLs to the International Space Station (ISS) for exposure to atomic oxygen and solar ultraviolet radiation.
• Analysis: 61 space-exposed lenses were analyzed alongside 20 terrestrial controls upon return to Earth.

Key Findings:

• 42 of the 61 lenses exposed to space showed no notable exposure-associated findings.
• 19 lenses exhibited changes, with 8 of 9 from the most exposed location developing cracks and surface roughening.
• 5 space-exposed IOLs showed yellow discoloration and reduced light transmission between 400 and 500 nm.
• All 6 light-adjustable lenses developed a distinctive cobblestone surface appearance.

Interpretation:

Some IOLs may be susceptible to damage from space exposure, necessitating further research.

Limitations:

• Sample sizes were small.
• IOLs were deliberately unpackaged, raising concerns about handling and contamination.
• The study was not designed to compare lens manufacturers or models.

Conclusion:

Further mechanical, optical, and clinical-performance testing is required, with future studies potentially involving phacoemulsification systems under microgravity conditions.

Sources:

• ESCRS Congress