Complex Ocular Surface Reconstruction Using AMT

Cryopreserved amniotic membranes can be a useful tool in the surgeon’s armamentarium.

By: Darren Gregory, MD

Ophthalmology Management May 18, 2026 Vol 30, Issue Cornea and Dry Eye 2026

Clinical Report: Complex Ocular Surface Reconstruction Using AMT

Overview

Cryopreserved amniotic membranes (CAMs) are effective in managing complex ocular surface diseases, particularly in patients with conditions like Stevens-Johnson syndrome and ocular cicatricial pemphigoid. They promote epithelial healing, reduce inflammation, and limit scar formation, making them a vital tool for surgeons.

Background

Complex ocular surface reconstruction is critical for patients with severe ocular conditions that impair healing, such as Stevens-Johnson syndrome and chemical injuries. Limbal stem cell deficiency and extensive adhesions complicate surgical interventions, necessitating effective strategies for reconstruction. Amniotic membrane transplantation (AMT) offers a biologically active solution to enhance healing and minimize complications.

Data Highlights

No numerical data or trial data provided in the source material.

Key Findings

Cryopreserved amniotic membranes can be used as temporary biologic bandages or permanent tissue substrates.
AMT promotes epithelial healing and reduces inflammation in complex ocular surface diseases.
Low-dose mitomycin C can be utilized to temper fibroblast activity without impairing healing.
Proper orientation and handling of the amniotic membrane are crucial for successful outcomes.
In larger pterygium cases, combining conjunctival autografts with amniotic membrane can enhance healing.

Clinical Implications

Surgeons should consider using cryopreserved amniotic membranes in complex ocular surface reconstructions to improve healing outcomes. Careful technique and management of fibroblast activity are essential to prevent complications while promoting recovery.

Conclusion

Amniotic membrane transplantation is a versatile and effective approach for managing complex ocular surface conditions, significantly aiding in patient recovery and minimizing complications.

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