Eric Donnenfeld, M.D., and Robert Snyder, M.D. say that while endophthalmitis is rare, it can be devastating and cost a patient his eyesight. However, with current therapy, you can limit or prevent the damage entirely. The authors recommend that you use fluoroquinolone antibiotics such as ofloxacin (Ocuflox), which is much more effective than traditional treatments such as dexamathasone (TobraDex) and vancomycin.